St. Gorgonia married a man of some influence in Pisidia, sometimes called Vitolian, and other times, Meletius. By at least one account, she is called the "pattern of a married saint." She had several sons and three daughters, the most notable of whom was named Alypania. Later in her life, she converted her husband, and was baptized along with him and her sons and grandsons.

St. Gregory the Theologian eulogized St. Gorgonia as "The Diamond of Her Sex"

Two times in her life, she was miraculously cured of serious maladies. The first of these was her having been trampled by a team of mules, causing her broken bones and crushed internal organs. Yet, Gorgonia would have no doctor, as she thought it indecent. According to the legend, it was this modesty which cured her.

Another time, she cured herself of a desperate illness by anointing herself with "the sacred elements of the Eucharist" mixed with her own tears, which she had shed with her head on the altar. She was cured of this disease as she was of the first, the symptoms of headache, fever, paralysis, and sporadic coma disappearing, allegedly, through the strength of her prayer.

St. Gorgonia died of natural causes. Her father and mother were alive, though extremely old, at the time of her death. At her funeral, her brother St. Gregory the Theologian preached a eulogy which declared her a model Christian spouse and mother, as well as "The Paragon of Women" and "The Diamond of Her Sex."